La Viola have picked up just two points from the last available nine in Serie A and are slight 27/20 (2.35)outsiders with BetVictor to emerge victorious against the champions.
Antonio Conte's men are undefeated so far this season and are available at 6/5 (2.20) to pick up a fifth-consecutive win in Tuscany.
Having drawn each of their last two home games, the hosts are on offer at 23/10 (3.30) to settle for a point once again this time out.
The home crowd have waited 15 years since their side last overcame their hated opponents at the Artemio Franchi but will be hard-pressed to end that run seeing as the visitors have only lost three of their last 38 league fixtures on the road.
However, with just two home defeats in their last 25, Vincenzo Montella's men are a force to be reckoned with in their own back yard and may take some optimism from the sloppiness that seems to have crept intola Vecchia Signora's usually impenetrable defence recently.
Having conceded four goals in their last two matches in all competitions, Conte's outfit have now kept just one clean sheet in their last eight games and will surely come under threat against last season's second top scorers, who have hit the back of the net in 40 of their last 45 league fixtures.A bet on both teams to score would have paid out in 13 of Fiorentina's last 17 Serie A matches on home soil and seven of Juventus' last eight matches in all competitions, so looks to be where the smart money lies when they come face to face, at generous 9/10 (1.90) odds.