Tuesday's games saw Portugal book their ticket for next summer's tournament at the expense of Sweden, as Cristiano Ronaldo netted four goals over two matches to help his side to a 4-2 aggregate win.
France, meanwhile, completed an impressive comeback at the Stade de France as they beat Ukraine 3-0 to overturn their 2-0 surprise loss from last Friday.
Elsewhere, Croatia eliminated Iceland as they recorded a 2-0 home win after a scoreless draw in the first leg last week. The final European ticket went to Greece, who sealed qualification with a 1-1 draw versus Romania after a 3-1 first-leg victory.
In Africa, Nigeria became the first team to make it to next year's finals as they beat Ethiopia 2-0 at the weekend to make it 4-1 on aggregate. Cote d'Ivoire also booked their ticket on Saturday as they held Senegal to a 1-1 draw following their first-leg win.
On Sunday, Cameroon qualified with a 4-1 home win over Tunisia, while Ghana eliminated Egypt 7-3 on aggregate despite their 2-1 defeat on Tuesday. Finally, Algeria sealed their World Cup berth following a 1-0 home-win over Burkina Faso that saw them qualify on away goals.
Wednesday's intercontinental play-off between Mexico and New Zealand then saw the former become the penultimate team to reach next summer's tournament. A 4-2 away-win more than proved enough after a heavy 5-1 victory in the first leg.
Later in the day, two-time champions Uruguay were surprisingly held to a 0-0 draw by Jordan in Montevideo, but still cruised through 5-0 on aggregate to become the 32nd and final side to qualify for next summer's finals in Brazil.