A Robert Lewandowski goal saw the Gunners crash to their first defeat in 13 games on Tuesday but they are heavy 1/3 (1.33) favourites with bet365 to move five points clear at the top of the Premier League table with victory in south London.
Ian Holloway handed in his resignation after leading his side to a fifth consecutive league defeat at home to Fulham on Monday night and caretaker manager Keith Millen is up against it at 17/2 (9.50) to end that run with a shock win against the Premier League leaders.
The last two meetings between this sides at this ground have ended in a draw, but there are long 4/1 (5.00) odds available on the struggling hosts earning a share of the spoils in their current predicament.
After acquiring an air of invincibility over the past few weeks, it was a shock to see Arsene Wenger’s men succumb to defeat on Tuesday, albeit against one of the finest teams in Europe.
The manner of their loss was particularly agonising for the players, who will be desperately champing at the bit to get back to winnings ways straight away, no doubt grateful for the early kick-off against struggling opposition.
The Eagles looked deflated as they went in behind at the break against Fulham and never recovered in a defeat that could realistically have been even heavier on another day, so it is perhaps no surprise Holloway felt compelled to fall on his sword, feeling he had done all he could at the helm.
That was the fourth time in the last five that Palace have trailed at both half-time and full time, and considering Arsenal have lead at the break in five of their six league wins this season, odds of 10/11 (1.91)surely cannot be ignored on them having the game wrapped up within 45 minutes when they come out all guns blazing on Saturday.