Jose Mourinho knows this game cannot be lost, as it would send Jens Keller's men six points ahead of them, making winning the group a tough task.
However, with Chelsea coming into this game in free scoring form, you can expect the Blues to come out firing this evening.
With five wins in their last six, Mourinho's side is starting to take shape after his return to Stamford Bridge, and William Hill price them as favourites at 5/4 (2.25).
After a sloppy start to the season, Schalke have really come into form over the past few weeks. Since losing to Hannover in the Bundesliga at the end of August, Keller's side have won eight of their last 10 matches, with their only loss coming against Bayern Munich.
The Royal Blues thumped Steaua Bucharest in their opening Champions League game, before fighting past Basel 1-0. William Hill price them at 21/10 (3.10) to take the three points. The same firm price the draw at12/5 (3.40).
A bet that stands out in this fixture is over 2.5 goals at 4/5 (1.80) with William Hill. With the both teams to score bet too short at 13/20, it's well worth backing three or more goals when you consider these teams aren't shy in front of goal.
This bet would have paid out in six of Schalke's last seven matches, as well as four of Chelsea's last five.
For those looking for more value, backing Chelsea to score over 1.5 goals at the price of 11/10 (2.10) with William Hill is well worth investing in.
This bet would have landed in five of the Blues' last six matches, and with Mourinho's side scoring 11 goals in their last three matches, it's tough to ignore this bet.